RCL uses CFFI to communicate with the R environment, RCLmath links with libRmath and makes some functions accessible in a much simpler way. The code is available under the MIT license. Note that there is another project working on communication between Common Lisp and R: RCLG.

rcl

This package gives access to the full R environment.

R 2.12.1 AllegroCL 8.2 CLISP 2.49 ClozureCL 1.6 CMUCL 20b ECL 11.1.1 LispWorks 6.0.1 SBCL 1.0.44
Windows/x86
Linux/x86 OK [1] OK [1]
MacOSX/x86 OK OK OK [1] OK OK OK OK [1]
MacOSX/PPC
R 2.9 AllegroCL 8.1 CLISP 2.47 ClozureCL 1.3 CMUCL 19f ECL 9.4.1 LispWorks 5.1.1 SBCL 1.0.26
Windows/x86 OK OK OK n/a OK OK OK
Linux/x86 OK OK OK OK OK OK OK
MacOSX/x86 OK no FFI OK [1] OK (r-init) crashes OK OK [1]
MacOSX/PPC OK OK OK OK OK [2] OK OK

A success means only that some basic operations work, no extensive testing is performed on any platform.

Download: rcl.tar.gz (older snapshots rcl-081007.tgz, rcl-080628.tgz, rcl-070316.tgz, rcl-060716.tgz,rcl-060703.tgz,rcl-060623.tgz).

(asdf-install:install "http://common-lisp.net/project/rcl/rcl.tar.gz")
or 
(ql:quickload :rcl)
 
Most likely you'll need to edit the library path in config.lisp; if rcl:*r-lib-loaded* is nil, try (cffi:load-foreign-library *r-lib*) to see what's the problem (see init.lisp).
CL-USER> (in-package :rcl)
#<PACKAGE "RCL">
R> (r-init)
T
R> (r "R.Version")
("i386-apple-darwin8.10.1" "i386" "darwin8.10.1" "i386, darwin8.10.1" "Patched"
 "2" "6.0" "2007" "10" "03" "43075" "R"
 "R version 2.6.0 Patched (2007-10-03 r43075)")
((:NAMES "platform" "arch" "os" "system" "status" "major" "minor" "year"
  "month" "day" "svn rev" "language" "version.string"))

When decoding an object with attributes, the list of attributes is returned as a secondary value (it's also possible to print attributes to standard-output whenever encountered decoding an object, to be aware of their existence).

In its current state it might be possible to use RCL successfully for simple tasks, but there are a number of issues: